Does urea formation have a feedback inhibition mechanism Explain the Essay

Does urea formation have a feedback inhibition mechanism Explain the why or why non - Essay ExampleCarbomyl phosphate synthase I acts as the rate limiting enzyme in urea cycle. N-acetylglutamate allosterically activates it thus lowering its Km for protein synthesis. Carbomyl Phosphate Synthase I binds with the master(a) ATP molecule and converts into a vigorous conformation. It then changes into a second form by binding with N-acetylglutamate thus enhancing its own ATP affinity. As a result, a phosphate group is transferred from a subsequent ATP to the enzyme bound carbamate. This changes the carbamate to carbomyl phosphate. This happens according to the Rubio-Britton-Grisolia model. Hence, it is seen that hepatic N-acetylglutamate controls the rate of protein synthesis in the urea cycle, by modulate its rate-limiting enzyme allosterically (Das 475). Arginine does not cause feedback inhibition of Carbomyl PS-1 or OTC but stimulates the activity of acetylglutamate synthetase.Howeve r, according to Snodgrass (67), in bacteria and fungi, arginine inhibits conversion of glutamate to acetylglutamate. Also, only at high stringency levels, orthinine transcarbomylase and argininosuccinate synthase undergo feedback inhibition mechanism by citrulline and argininosuccinate, which are their respective